Oocyte meiotic spindle assembly and function
Web13 de abr. de 2024 · For example, oocyte quality, embryonic development, and fertility can be restored by nicotinamide mononucleotide treatment in aged mice . Germline nuclear transfer, including germinal vesicle, pronuclear, and spindle transfer, is a potential strategy for improving the meiotic competence of aged mouse and human oocytes (93, 94). Web13 de nov. de 2012 · The microtubule-associated protein ASPM (abnormal spindle-like microcephaly-associated) plays an important role in spindle organization and cell …
Oocyte meiotic spindle assembly and function
Did you know?
Web10 de abr. de 2024 · In starfish oocytes, actin drives chromosome clustering after NEBD 2,3. In mouse oocytes, a Formin-2/Spire-nucleated actin network is responsible for spindle … Web16 de dez. de 2024 · LRRK2 is mainly accumulated at the meiotic spindle periphery during oocyte maturation. Depleting LRRK2 led to the polar body extrusion defects and also induced large polar bodies in mouse oocytes.
WebTo this end, the oocyte eliminates half of its chromosomes into a small cell termed a polar body. The egg is then released into the Fallopian tube, where it can be fertilized. Upon … Web22 de nov. de 2024 · Actin takes over various essential function during oocyte meiosis, many of which commonly rely on microtubules in mitotic cells. Specifically, the actin network has been linked to long-range vesicle transport, nuclear positioning, spindle migration and anchorage, polar body extrusion and accurate chromosome segregation in mammalian …
Web10 de mai. de 2011 · Here, we report Ndc80 expression, localization, and possible functions in mouse oocyte meiosis. Ndc80 mRNA levels gradually increased during meiosis. Immunofluorescent staining showed that Ndc80 was restricted to the germinal vesicle and associated with spindle microtubules from the Pro-MI to MII stages. Web1 de jan. de 2016 · Systematic investigations of how microtubule–kinetochore attachments, and kinetochore function more generally, influence spindle assembly and …
Web1 de mai. de 2012 · Oocyte meiosis is acentrosomal. In most eukaryotic organisms, sexual reproduction relies on a specialized type of cell division termed meiosis that generates a …
Web10 de abr. de 2024 · Importantly, clustering of chromosomes is a prerequisite to their correct and complete capture by the meiotic spindle ( Figure 1 B). This work adds to a growing body of evidence that actin can also be responsible for chromosome movements and capture, a function generally attributed to microtubules. In starfish oocytes, actin drives … simplicity\u0027s uiWeb5 de dez. de 2016 · Meiotic spindle assembly and chromosome segregation in oocytes. Oocytes accumulate maternal stores (proteins, mRNAs, metabolites, etc.) during their … simplicity\u0027s ulWebA new function for AURKC in bipolar spindle assembly was recently described in mouse oocytes. By changing fixation conditions to preserve MTOC structure, active AURKC was discovered to also co-localize to MTOCs during meiotic maturation ( Fig. 2, Key Figure) [ … simplicity\\u0027s uiWebSemantic Scholar extracted view of "Oocyte Meiotic Spindle Assembly and Function." by A. Severson et al. Skip to search form Skip to main content Skip to account menu. Semantic Scholar's Logo. Search 206,780,888 papers from all fields of science. Search. Sign In Create Free Account. simplicity\u0027s ukWebof oocyte cytoplasm was previously described in starfish oocytes2–4. After NEBD, most of the chromosomes are out of reach of microtubule asters, the precursors of the meiotic spindle positioned at the animal pole of the oocyte. However, an actin shell is polymerized on the inner side of the nuclear envelope seconds before the start of NEBD2. simplicity\\u0027s ujWebOocyte Meiotic Spindle Assembly and Function. @article{Severson2016OocyteMS, title={Oocyte Meiotic Spindle Assembly and Function.}, author={Aaron F Severson … raymond isin codeWeb30 de mai. de 2024 · CDCA8 regulates meiotic spindle assembly and ... to the relevant destinations as different stages of mitosis and interact with its different substrates for … simplicity\\u0027s ul